SelenoDB
Release 2.0
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Gene Report for SPG00000001_2.0
Identity
GeneIodothyronine deiodinase 1 (DI1)
SpeciesHomo sapiens (Human)
DescriptionIt activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3-prime,5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). (NCBI)
FamilyIodothyronine deiodinase
Synonyms Iodothyronine deiodinase (DIO)
Subfamily Iodothyronine deiodinase 1 (DI1)
Synonyms Iodothyronine deiodinase 1 (DIO1)
Gene IDSPG00000001
Gene release2.0
External ID ENSG00000211452.6 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
Thermodynamic pattern-based SECIS prediction (SECISearch, 3.0) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000002_2.0SPR00000003_2.0SPP00000002_2.0SPS00000001_2.0
SPT00000003_2.0SPR00000004_2.0SPP00000003_2.0SPS00000002_2.0
SPT00000001_2.0SPR00000002_2.0SPP00000001_2.0N/A
SPT00000005_2.0SPR00000006_2.0SPP00000005_2.0N/A
SPT00000004_2.0SPR00000005_2.0SPP00000004_2.0N/A
SPT00000006_2.0SPR00000007_2.0SPP00000006_2.0N/A
SPT00000007_2.0SPR00000008_2.0SPP00000007_2.0N/A
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.379
Middle East0.5450.452
Europe0.4290.3470.288
Central-South Asia0.4950.4580.3310.360
East Asia0.3140.3210.3210.2320.171
Oceania0.3660.2530.2840.1800.2820.209
America0.3810.2400.2680.2100.3350.2760.386

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.229
Middle East0.7730.434
Europe0.7070.3610.122
Central-South Asia0.5100.2790.1540.117
East Asia0.7550.0020.0000.0040.092
Oceania0.5500.3530.4970.6940.8370.417
America0.1170.0760.0550.1170.0000.5750.100

Low P-value

High P-value

Sequence
Sequence SEQ00000001_2.0
External ID ENSG00000211452.6 (Ensembl)
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