SelenoDB
Release 2.0
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Gene Report for SPG00000003_2.0
Identity
GeneIodothyronine deiodinase 3 (DI3)
SpeciesHomo sapiens (Human)
DescriptionIt catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3-prime,5-triiodothyronine (T3) to inactive metabolites, 3,3-prime,5-prime-triiodothyronine (RT3) and 3,3-prime-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. (NCBI)
FamilyIodothyronine deiodinase
Synonyms Iodothyronine deiodinase (DIO)
Subfamily Iodothyronine deiodinase 3 (DI3)
Synonyms Iodothyronine deiodinase 3 (DIO3)
Gene IDSPG00000003
Gene release2.0
External ID ENSG00000197406.5 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Thermodynamic pattern-based SECIS prediction (SECISearch, 3.0) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000016_2.0SPR00000019_2.0SPP00000016_2.0SPS00000005_2.0
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.345
Middle East0.6060.579
Europe0.4220.4590.326
Central-South Asia0.4290.3770.2890.217
East Asia0.4470.4050.3090.3730.155
Oceania0.4700.3100.3360.3800.4560.016
America0.4190.1540.1940.1830.3560.1680.272

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.203
Middle East0.0400.095
Europe0.6300.0280.339
Central-South Asia0.6190.2310.4010.000
East Asia0.0000.0000.0010.0000.999
Oceania0.0640.1570.0780.0150.0050.750
America0.0250.7540.4950.5480.0000.7880.251

Low P-value

High P-value

Sequence
Sequence SEQ00000003_2.0
External ID ENSG00000197406.5 (Ensembl)
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