SelenoDB
Release 2.0
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Gene Report for SPG00000007_2.0
Identity
GeneGlutathione peroxidase 4 (GPx4)
SpeciesHomo sapiens (Human)
DescriptionGlutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Highly expressed in the sperm. (NCBI)
FamilyGlutathione peroxidase
SynonymsNone
Subfamily Glutathione peroxidase 4 (GPx4)
Synonyms Mithocondrial capsule selenoprotein (MCSP)
Phospholipd glutathione peroxidase (PHGPx)
Gene IDSPG00000007
Gene release2.0
External ID ENSG00000167468.11 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Thermodynamic pattern-based SECIS prediction (SECISearch, 3.0) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000026_2.0SPR00000033_2.0SPP00000026_2.0SPS00000011_2.0
SPT00000027_2.0SPR00000034_2.0SPP00000027_2.0SPS00000012_2.0
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.335
Middle East0.5780.540
Europe0.4370.3950.271
Central-South Asia0.4970.4560.2870.315
East Asia0.4280.3780.3930.3700.330
Oceania0.4860.4740.5380.5040.5140.575
America0.3210.2510.3130.2930.3180.4780.438

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.444
Middle East0.6180.293
Europe0.6240.1380.154
Central-South Asia0.4650.2580.3220.365
East Asia0.0010.0000.0000.0000.000
Oceania0.0790.0270.0030.0030.0090.167
America0.5910.0740.0090.0010.0000.1180.042

Low P-value

High P-value

Sequence
Sequence SEQ00000007_2.0
External ID ENSG00000167468.11 (Ensembl)
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