SelenoDB
Release 2.0
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Gene Report for SPG00000008_2.0
Identity
GeneGlutathione peroxidase 5 (GPx5)
SpeciesHomo sapiens (Human)
DescriptionThis gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. (NCBI)
FamilyGlutathione peroxidase
SynonymsNone
Subfamily Glutathione peroxidase 5 (GPx5)
SynonymsNone
Gene IDSPG00000008
Gene release2.0
External ID ENSG00000224586.2 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000032_2.0SPR00000040_2.0SPP00000036_2.0N/A
SPT00000033_2.0SPR00000041_2.0SPP00000037_2.0N/A
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.379
Middle East0.7090.631
Europe0.6100.5180.448
Central-South Asia0.5810.5860.5300.486
East Asia0.4560.3800.4660.3160.312
Oceania0.4490.2310.2810.2610.4720.597
America0.2640.1900.2310.1430.0920.3570.184

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.227
Middle East0.0110.169
Europe0.0000.0470.013
Central-South Asia0.0030.0040.0000.002
East Asia0.0000.0000.0000.0000.000
Oceania0.1160.5500.6210.5420.0540.167
America0.9070.3540.1760.8561.0000.2860.441

Low P-value

High P-value

Sequence
Sequence SEQ00000008_2.0
External ID ENSG00000224586.2 (Ensembl)
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