SelenoDB
Release 2.0
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Gene Report for SPG00000038_2.0
Identity
GeneThioredoxin reductase 2 (TR2)
SpeciesHomo sapiens (Human)
DescriptionThioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. (NCBI)
FamilyThioredoxin reductase
Synonyms Thioredoxin reductase (TrxR)
Subfamily Thioredoxin reductase 2 (TR2)
Synonyms Selenoprotein Z (SelZ)
Thioredoxin reductase 3 (TR3)
Thioredoxin reductase 2 (TrxR2)
Gene IDSPG00000038
Gene release2.0
External ID ENSG00000184470.15 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Thermodynamic pattern-based SECIS prediction (SECISearch, 3.0) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationReverse
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000129_2.0SPR00000167_2.0SPP00000137_2.0SPS00000045_2.0
SPT00000130_2.0SPR00000168_2.0SPP00000138_2.0SPS00000046_2.0
SPT00000131_2.0SPR00000169_2.0SPP00000139_2.0SPS00000047_2.0
SPT00000132_2.0SPR00000170_2.0SPP00000140_2.0SPS00000048_2.0
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.288
Middle East0.5580.506
Europe0.4310.3790.251
Central-South Asia0.4840.4400.3150.359
East Asia0.4800.3770.3980.3450.407
Oceania0.4180.3310.3360.2940.4210.341
America0.4150.2720.3100.2470.3370.3110.350

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.678
Middle East0.6820.390
Europe0.7650.3180.253
Central-South Asia0.4870.3280.2110.077
East Asia0.0000.0000.0000.0000.000
Oceania0.3090.1850.2920.2450.1670.333
America0.0480.0300.0080.0150.0000.4790.125

Low P-value

High P-value

Sequence
Sequence SEQ00000038_2.0
External ID ENSG00000184470.15 (Ensembl)
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