SelenoDB
Release 2.0
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Gene Report for SPG00001120_2.0
Identity
GeneIodothyronine deiodinase 2 (DI2)
SpeciesLatimeria chalumnae (Coelacanth)
DescriptionIt activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3-prime,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. (NCBI)
FamilyIodothyronine deiodinase
Synonyms Iodothyronine deiodinase (DIO)
Subfamily Iodothyronine deiodinase 2 (DI2)
Synonyms Iodothyronine deiodinase 2 (DIO2)
Gene IDSPG00001120
Gene release2.0
External IDNone
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Thermodynamic pattern-based SECIS prediction (SECISearch, 3.0) [Report annotation error]
(Selenoprofiles, Ensembl 68) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00001216_2.0SPR00001281_2.0SPP00001224_2.0SPS00000563_2.0
Sequence
Sequence SEQ00001119_2.0
External IDNone
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